AOD9604
February 15, 2024Incremental
4/10
Purrptide digest
AOD9604 is a fragment of growth hormone — just the piece responsible for fat metabolism, snipped away from the parts that affect blood sugar and growth. That surgical precision was the whole point. Full GH raises blood sugar and risks acromegaly with long-term use; this fragment was designed to dodge both. Clinical trials showed modest fat loss without the metabolic side effects of full-length GH. Modest, but clean.
What this means for you
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If you care about weight/health
A more targeted fat-loss tool than full GH peptides, with a cleaner side-effect profile — modest results, but predictable ones.
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If you're a clinician
Engineered specifically to avoid the diabetogenic and growth-promoting effects of full-length GH. Worth knowing the mechanism if patients ask.
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If you're a researcher
Fragment-based drug design isolating a single functional domain of a larger hormone is a reusable strategy worth studying beyond just GH.
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If you follow biotech
A fat-loss-specific GH fragment without the diabetes risk is a cleaner regulatory story than full GH analogues.
HE
Heffernan et al.
Monash University
For the nerds
The lipolytic and anti-lipogenic effects of the AOD9604 GH fragment
Diabetes, Obesity and Metabolism · DOI: 10.1046/j.1463-1326.2001.00126.x
Read full paper on PubMed →