Humanin
Effect Profile
How Humanin scores across 8 body systems
25
/ 80 total
Top strengths
Purrptide digest
Humanin was discovered almost by accident, isolated from cells surviving Alzheimer's-related stress that should have killed them. It's a literal survival signal. Like MOTS-c, it's mitochondrial-genome encoded — these two peptides keep showing up together in longevity research for that reason. Levels of Humanin decline with age in humans, and supplementing it in animal models extends lifespan and protects neurons from multiple types of cellular stress.
What this means for you
Naturally declining levels with age put this firmly in 'replace what you're losing' territory for the longevity-focused crowd.
Cytoprotective effects against multiple stressors (not just one disease pathway) is what makes this interesting beyond a single indication.
Discovered through Alzheimer's-resistant cell survival research — the origin story alone is worth understanding for context on its mechanism.
Another mitochondrial-derived peptide with longevity signal. This category is quietly becoming one of the more credible areas in the space.
For the nerds
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta
PNAS · DOI: 10.1073/pnas.231165798
Read full paper on PubMed →