Hexarelin
May 18, 2024Promising
5/10
Purrptide digest
Hexarelin produces the strongest GH pulse of any secretagogue peptide — louder than Ipamorelin, louder than GHRP-2, loud enough that researchers started checking other organs for side effects. What they found instead was a direct cardioprotective effect, independent of growth hormone entirely. The heart has its own receptors for this thing. The tradeoff: it also raises cortisol and prolactin more than the 'cleaner' secretagogues, which is the price of that bigger pulse.
What this means for you
🏃
If you care about weight/health
Maximum GH pulse comes with maximum side effects too — cortisol and prolactin go up along with it. Not the beginner-friendly option.
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If you're a clinician
The independent cardioprotective mechanism via non-GH receptors is the genuinely novel finding here, separate from the secretagogue effect.
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If you're a researcher
Cardiac-specific ghrelin receptor binding that operates independently of GH release deserves its own dedicated research track.
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If you follow biotech
A cardioprotective peptide that isn't primarily a GH drug is a different market entirely. Underexploited angle.
GH
Ghigo et al.
University of Turin
For the nerds
Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide
Journal of Clinical Endocrinology & Metabolism · DOI: 10.1210/jcem.79.4.7525636
Read full paper on PubMed →